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This randomized, double‑blind, placebo‑controlled trial investigated the gut‑healing effects of the isolated hydroxycinnamic acid amide N‑trans caffeoyltyramine (NCT) in adults with diarrhea‑predominant IBS. Over three weeks, oral supplementation significantly improved intestinal barrier integrity, shown by a reduced Lactulose/Mannitol ratio (𝑝 = 0.048), and lowered systemic inflammation through decreased lipopolysaccharide‑binding protein levels (𝑝= 0.018) compared to… Read More
The study evaluates how the bacterial effector protein IpaH2, an E3 ubiquitin ligase produced by Shigella flexneri, influences viral infection mechanisms within host cells. The researchers identified plakophilin-2 (PKP2), a cellular adhesion and signaling protein, as a previously unrecognized host restriction factor that limits the replication of Sindbis virus. Through its ubiquitin ligase activity, IpaH2… Read More
Stinging nettle (Urtica dioica) root is used for benign prostatic hyperplasia. Researchers tested four nettle substances for effects on sex hormone–binding globulin (SHBG) binding to prostate membranes. Only the aqueous extract inhibited SHBG binding, starting at ~0.6 mg/ml and fully blocking it at 10 mg/ml, suggesting a water-soluble compound may underlie nettle’s prostate effects. Source… Read More
A small human trial tested whether rapidly absorbed boron affects steroid hormones and inflammation after single-dose and short-term use. Healthy men took a boron capsule once and then daily for several days; plasma boron rose within hours and stayed elevated.Within hours, SHBG, hsCRP and TNF-α fell. After the supplementation period, free testosterone rose while estradiol… Read More
In a randomized trial, emulsifiers reduced beneficial short-chain fatty acids and altered gut microbiota but did not increase inflammation or metabolic risk. Carrageenan increased gut permeability. An emulsifier-free diet lowered cholesterol. Results suggest limiting emulsifiers may support gut health. Source : https://pubmed.ncbi.nlm.nih.gov/41094562/ Read More