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Ameliorative role of Cyanus depressus (M.Bieb.) Soják plant extract against diabetes-associated oxidative-stress-induced liver, kidney, and pancreas damage in rats
Cyanus depressus (CD) ethanolic extract administered at 400 mg/kg/day for 21 days significantly reduced hyperglycemia, HbA1c, AST, ALT, LDH, urea, and oxidative stress markers in STZ-induced diabetic rats, while increasing GSH, GST, CAT, body weight, and pancreatic islet diameter and area. CD treatment also improved the histological integrity of the liver, kidneys, and pancreatic islets. Read More
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Beetroot Juice and Heart Health After Menopause
Heart disease is the top killer of women, especially after menopause. Beetroot juice, rich in natural nitrates, may help blood vessels work better. This study tested daily beetroot shots in women at early and late menopause stages. Participants drank nitrate-rich or placebo juice for a week. Blood vessel function was checked before and after the Read More
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Puerarin and the Gut–Liver–Brain Axis in Depression
The study investigated puerarin, a flavonoid from Pueraria lobata, for its antidepressant effects through the gut–liver–brain axis. Puerarin improved depression-related behavioral changes while helping restore gut microbiota balance, particularly by increasing beneficial Lactobacillaceae and Lactobacillus and reducing potentially harmful bacterial groups. It also improved intestinal and liver health and reduced LPS, AST, and ALP, indicating Read More
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Efficacy of Cyanotis tuberosa (Roxb.) Schult. &Schult. f. root tubers’ active fraction as anti-diabetic, antihyperlipidemic and antioxidant in Streptozotocin-induced diabetic rats
Cyanotis tuberosa root tuber extract and its active fraction (CTAF) demonstrated significant antihyperglycemic effects in STZ-induced diabetic rats, improving glycemic control, HbA1c, insulin resistance, plasma insulin, and lipid profiles. CTAF also reduced lipid peroxidation, restored antioxidant enzyme activities, and normalized liver and kidney functional markers. LC-ESI-MS/MS identified seven phytoconstituents, suggesting that C. tuberosa root tubers Read More
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Object Recognition Test (ORT): A Versatile Tool for Memory Research in Mice
The Object Recognition Test (ORT) is a widely used, low-stress behavioral assay to evaluate learning and memory in mice over a simple 3-day protocol: habituation, training, and testing. Mice naturally prefer novelty, so during testing they spend more time exploring a new object if they remember the familiar one eliminating the need for rewards, punishments, Read More