Cyanus depressus (CD) ethanolic extract administered at 400 mg/kg/day for 21 days significantly reduced hyperglycemia, HbA1c, AST, ALT, LDH, urea, and oxidative stress markers in STZ-induced diabetic rats, while increasing GSH, GST, CAT, body weight, and pancreatic islet diameter and area. CD treatment also improved the histological integrity of the liver, kidneys, and pancreatic islets. These antidiabetic and antioxidant effects were attributed to its phytochemical constituents, particularly quinic acid, cosmosiin, nicotiflorin, apigenin, and protocatechuic acid, suggesting potential for mitigating diabetes and its associated complications.
