{"id":1119,"date":"2025-11-18T12:08:15","date_gmt":"2025-11-18T12:08:15","guid":{"rendered":"https:\/\/snips.nutrifytoday.com\/blog\/?p=1119"},"modified":"2025-11-18T12:08:15","modified_gmt":"2025-11-18T12:08:15","slug":"fermented-mushroom-extract-protects-gut-barrier-and-reduces-inflammation","status":"publish","type":"post","link":"https:\/\/snips.nutrifytoday.com\/blog\/fermented-mushroom-extract-protects-gut-barrier-and-reduces-inflammation\/","title":{"rendered":"Fermented Mushroom Extract Protects Gut Barrier and Reduces Inflammation"},"content":{"rendered":"\n<p>A new study highlights the potential of Pleurotus eryngii mushroom fermentation supernatant (FS-PEWS) in safeguarding intestinal health. Using an in vitro Caco-2 cell model and ex vivo colonic biopsies, researchers found that FS-PEWS counteracted sodium deoxycholate (SDC)-induced gut barrier damage by restoring key tight junction proteins ZO-1 and claudin-1. The supernatant also reduced pro-inflammatory cytokines, including TNF-\u03b1, IL-6, and IL-1\u03b2, while modulating immune pathways like TLR-4 and dectin-1. These findings suggest FS-PEWS could be a promising intervention for gut barrier dysfunction and inflammation linked to microbial metabolite disturbances.<\/p>\n\n\n\n<p>Source: <a href=\"https:\/\/www.mdpi.com\/2072-6643\/17\/4\/694\">https:\/\/www.mdpi.com\/2072-6643\/17\/4\/694<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new study highlights the potential of Pleurotus eryngii mushroom fermentation supernatant (FS-PEWS) in safeguarding intestinal health. Using an in vitro Caco-2 cell model and ex vivo colonic biopsies, researchers found that FS-PEWS counteracted sodium deoxycholate (SDC)-induced gut barrier damage by restoring key tight junction proteins ZO-1 and claudin-1. The supernatant also reduced pro-inflammatory cytokines, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1119","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts\/1119","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/comments?post=1119"}],"version-history":[{"count":1,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts\/1119\/revisions"}],"predecessor-version":[{"id":1120,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts\/1119\/revisions\/1120"}],"wp:attachment":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/media?parent=1119"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/categories?post=1119"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/tags?post=1119"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}