{"id":1295,"date":"2025-11-21T07:21:40","date_gmt":"2025-11-21T07:21:40","guid":{"rendered":"https:\/\/snips.nutrifytoday.com\/blog\/?p=1295"},"modified":"2025-11-21T07:21:40","modified_gmt":"2025-11-21T07:21:40","slug":"pea-fine-tunes-the-gut-microbiome-and-reduces-triglycerides-in-overweight-adults","status":"publish","type":"post","link":"https:\/\/snips.nutrifytoday.com\/blog\/pea-fine-tunes-the-gut-microbiome-and-reduces-triglycerides-in-overweight-adults\/","title":{"rendered":"PEA Fine-Tunes the Gut Microbiome and Reduces Triglycerides in Overweight Adults"},"content":{"rendered":"\n<p>A 12-week randomized trial explored how palmitoylethanolamide (PEA) affects the gut microbiome and health markers in overweight adults (n=58, BMI 30\u201340). Participants received either PEA (n=36) or placebo (n=22).<\/p>\n\n\n\n<p>PEA supplementation significantly lowered serum triglycerides and IL-2 levels. Gut microbiota composition, richness, and diversity showed no major group differences, but pathway analysis revealed targeted effects: reduced aromatic compound degradation, NAD interconversion, and L-glutamate degradation, alongside increased molybdopterin biosynthesis and O-antigen building block pathways. The latter may enhance smooth LPS formation, linked to reduced pathogenic persistence.<\/p>\n\n\n\n<p>These findings suggest PEA may fine-tune microbial functions and host metabolic health, offering a potential strategy for managing inflammation and triglyceride levels in overweight individuals.<\/p>\n\n\n\n<p>Source: <a href=\"https:\/\/www.mdpi.com\/2227-9059\/12\/7\/1620\">https:\/\/www.mdpi.com\/2227-9059\/12\/7\/1620<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A 12-week randomized trial explored how palmitoylethanolamide (PEA) affects the gut microbiome and health markers in overweight adults (n=58, BMI 30\u201340). Participants received either PEA (n=36) or placebo (n=22). PEA supplementation significantly lowered serum triglycerides and IL-2 levels. Gut microbiota composition, richness, and diversity showed no major group differences, but pathway analysis revealed targeted effects: [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1295","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts\/1295","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/comments?post=1295"}],"version-history":[{"count":1,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts\/1295\/revisions"}],"predecessor-version":[{"id":1296,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts\/1295\/revisions\/1296"}],"wp:attachment":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/media?parent=1295"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/categories?post=1295"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/tags?post=1295"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}