{"id":1303,"date":"2025-11-21T07:23:27","date_gmt":"2025-11-21T07:23:27","guid":{"rendered":"https:\/\/snips.nutrifytoday.com\/blog\/?p=1303"},"modified":"2025-11-21T07:23:27","modified_gmt":"2025-11-21T07:23:27","slug":"isomaltulose-preload-timing-modulates-incretin-response-and-second-meal-effect-in-metabolic-syndrome","status":"publish","type":"post","link":"https:\/\/snips.nutrifytoday.com\/blog\/isomaltulose-preload-timing-modulates-incretin-response-and-second-meal-effect-in-metabolic-syndrome\/","title":{"rendered":"Isomaltulose Preload Timing Modulates Incretin Response and Second Meal Effect in Metabolic Syndrome"},"content":{"rendered":"\n<p>Low-glycemic carbohydrate isomaltulose (ISO) supports incretin release and improves postprandial control via the second meal effect (SME), relevant for metabolic syndrome (MetS). In a randomized crossover trial, 15 MetS subjects received ISO or sucrose (SUC) preloads 1 h or 3 h before a test meal. ISO blunted glucose rise (\u0394G\/\u0394t: 0.28 vs. 0.53 mmol\/L\/min, p&lt;0.01), sustained GLP-1 and PYY, while SUC drove higher GIP. Preload timing shaped outcomes: ISO at 3 h enhanced PYY and SME more than at 1 h. ISO, especially with a 3 h preload, shows potential to optimize postprandial glycemia in MetS.<\/p>\n\n\n\n<p>Source: <a href=\"https:\/\/www.mdpi.com\/2072-6643\/17\/15\/2539\">https:\/\/www.mdpi.com\/2072-6643\/17\/15\/2539<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Low-glycemic carbohydrate isomaltulose (ISO) supports incretin release and improves postprandial control via the second meal effect (SME), relevant for metabolic syndrome (MetS). In a randomized crossover trial, 15 MetS subjects received ISO or sucrose (SUC) preloads 1 h or 3 h before a test meal. ISO blunted glucose rise (\u0394G\/\u0394t: 0.28 vs. 0.53 mmol\/L\/min, p&lt;0.01), [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1303","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts\/1303","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/comments?post=1303"}],"version-history":[{"count":1,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts\/1303\/revisions"}],"predecessor-version":[{"id":1304,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts\/1303\/revisions\/1304"}],"wp:attachment":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/media?parent=1303"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/categories?post=1303"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/tags?post=1303"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}