{"id":1365,"date":"2025-11-21T07:37:50","date_gmt":"2025-11-21T07:37:50","guid":{"rendered":"https:\/\/snips.nutrifytoday.com\/blog\/?p=1365"},"modified":"2025-11-21T07:37:50","modified_gmt":"2025-11-21T07:37:50","slug":"randomized-clinical-trial-in-cancer-patients-shows-immune-metabolic-effects-exerted-by-formulated-bioactive-phenolic-diterpenes-with-potential-clinical-benefits","status":"publish","type":"post","link":"https:\/\/snips.nutrifytoday.com\/blog\/randomized-clinical-trial-in-cancer-patients-shows-immune-metabolic-effects-exerted-by-formulated-bioactive-phenolic-diterpenes-with-potential-clinical-benefits\/","title":{"rendered":"Randomized clinical trial in cancer patients shows immune metabolic effects exerted by formulated bioactive phenolic diterpenes with potential clinical benefits"},"content":{"rendered":"\n<p>In this randomized, double-blind, parallel clinical trial involving 108 patients with solid tumours (lung, colorectal, breast) receiving chemo\/targeted\/immunotherapy, researchers tested a novel nutraceutical formulation (Lipchronic\u00ae) comprised of a supercritical rosemary extract high in phenolic diterpenes (carnosic acid\/carnosol) combined with alkylglycerols to enhance bioavailability. The formulation was well tolerated, with no major adverse safety signals, and produced significant immune-metabolic modulation: in the lung cancer subgroup it reduced key inflammation biomarkers such as the neutrophil-to-lymphocyte ratio (NLR), increased lymphocyte percentages, decreased neutrophils, and shifted T-cell subpopulations toward effector\/memory phenotypes.<\/p>\n\n\n\n<p>Source : <a href=\"https:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2025.1519978\">https:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2025.1519978<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In this randomized, double-blind, parallel clinical trial involving 108 patients with solid tumours (lung, colorectal, breast) receiving chemo\/targeted\/immunotherapy, researchers tested a novel nutraceutical formulation (Lipchronic\u00ae) comprised of a supercritical rosemary extract high in phenolic diterpenes (carnosic acid\/carnosol) combined with alkylglycerols to enhance bioavailability. The formulation was well tolerated, with no major adverse safety signals, and [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1365","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts\/1365","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/comments?post=1365"}],"version-history":[{"count":1,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts\/1365\/revisions"}],"predecessor-version":[{"id":1366,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts\/1365\/revisions\/1366"}],"wp:attachment":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/media?parent=1365"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/categories?post=1365"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/tags?post=1365"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}