{"id":1429,"date":"2025-11-29T12:57:27","date_gmt":"2025-11-29T12:57:27","guid":{"rendered":"https:\/\/snips.nutrifytoday.com\/blog\/?p=1429"},"modified":"2025-11-29T12:57:27","modified_gmt":"2025-11-29T12:57:27","slug":"meta-analysis-of-shotgun-sequencing-of-gut-microbiota-in-parkinsons-disease","status":"publish","type":"post","link":"https:\/\/snips.nutrifytoday.com\/blog\/meta-analysis-of-shotgun-sequencing-of-gut-microbiota-in-parkinsons-disease\/","title":{"rendered":"Meta-analysis of shotgun sequencing of gut microbiota in Parkinson\u2019s disease"},"content":{"rendered":"\n<p>The study pooled shotgun metagenomic data from multiple countries and found that Parkinson\u2019s disease (PD) is consistently associated with higher gut microbial diversity, increased Akkermansia, and reduced SCFA-producing bacteria like Roseburia and Faecalibacterium. Functionally, PD guts showed a strong loss of microbial genes for riboflavin (B2) and biotin (B7) synthesis and reduced carbohydrate-metabolizing enzymes, indicating impaired microbial metabolism. Fecal metabolomics confirmed lower SCFAs and polyamines. The authors propose that reduced microbial vitamin synthesis \u2192 reduced SCFAs\/polyamines \u2192 weakened gut barrier \u2192 increased inflammation and \u03b1-synuclein aggregation in gut nerves, forming a mechanistic pathway linking gut dysbiosis to Parkinson\u2019s disease.<\/p>\n\n\n\n<p>Source : <a href=\"https:\/\/www.researchgate.net\/publication\/380764955_Meta-analysis_of_shotgun_sequencing_of_gut_microbiota_in_Parkinson%27s_disease\">https:\/\/www.researchgate.net\/publication\/380764955_Meta-analysis_of_shotgun_sequencing_of_gut_microbiota_in_Parkinson%27s_disease<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The study pooled shotgun metagenomic data from multiple countries and found that Parkinson\u2019s disease (PD) is consistently associated with higher gut microbial diversity, increased Akkermansia, and reduced SCFA-producing bacteria like Roseburia and Faecalibacterium. Functionally, PD guts showed a strong loss of microbial genes for riboflavin (B2) and biotin (B7) synthesis and reduced carbohydrate-metabolizing enzymes, indicating [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1429","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts\/1429","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/comments?post=1429"}],"version-history":[{"count":1,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts\/1429\/revisions"}],"predecessor-version":[{"id":1430,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts\/1429\/revisions\/1430"}],"wp:attachment":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/media?parent=1429"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/categories?post=1429"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/tags?post=1429"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}