{"id":1457,"date":"2025-12-12T09:42:18","date_gmt":"2025-12-12T09:42:18","guid":{"rendered":"https:\/\/snips.nutrifytoday.com\/blog\/?p=1457"},"modified":"2025-12-12T09:42:18","modified_gmt":"2025-12-12T09:42:18","slug":"attenuation-of-malignant-phenotype-of-glioblastoma-following-a-short-course-of-the-pro-oxidant-combination-of-resveratrol-and-copper","status":"publish","type":"post","link":"https:\/\/snips.nutrifytoday.com\/blog\/attenuation-of-malignant-phenotype-of-glioblastoma-following-a-short-course-of-the-pro-oxidant-combination-of-resveratrol-and-copper\/","title":{"rendered":"Attenuation of malignant phenotype of glioblastoma following a short course of the pro-oxidant combination of Resveratrol and Copper"},"content":{"rendered":"\n<p>Resveratrol\u2013Copper (R\u2011Cu) treatment in GBM patients deactivated cell\u2011free chromatin particles in the tumour microenvironment, leading to strong suppression of proliferation markers, cancer hallmarks, immune checkpoints, and stem\u2011cell biomarkers. Transcriptomic analysis showed increased pro\u2011apoptotic and decreased anti\u2011apoptotic gene expression, including down\u2011regulation of the PD\u2011L1\u2013like checkpoint PVRIG\u20112P. These findings suggest that low\u2011dose R\u2011Cu may significantly attenuate GBM aggressiveness.<\/p>\n\n\n\n<p>Source : <a href=\"https:\/\/www.nature.com\/articles\/s44276-025-00177-8\">https:\/\/www.nature.com\/articles\/s44276-025-00177-8<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Resveratrol\u2013Copper (R\u2011Cu) treatment in GBM patients deactivated cell\u2011free chromatin particles in the tumour microenvironment, leading to strong suppression of proliferation markers, cancer hallmarks, immune checkpoints, and stem\u2011cell biomarkers. Transcriptomic analysis showed increased pro\u2011apoptotic and decreased anti\u2011apoptotic gene expression, including down\u2011regulation of the PD\u2011L1\u2013like checkpoint PVRIG\u20112P. These findings suggest that low\u2011dose R\u2011Cu may significantly attenuate GBM [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1457","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts\/1457","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/comments?post=1457"}],"version-history":[{"count":1,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts\/1457\/revisions"}],"predecessor-version":[{"id":1458,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts\/1457\/revisions\/1458"}],"wp:attachment":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/media?parent=1457"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/categories?post=1457"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/tags?post=1457"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}