Hafnia alvei HA4597 is a clinically studied probiotic strain formulated to support the body\u2019s natural satiety signaling via the gut-brain axis. It works by stimulating production of ClpB, a bacterial protein that promotes the release of GLP-1 and PYY, two hormones central to appetite regulation and fullness\u2014helping individuals feel satisfied sooner, reduce cravings, and better control calorie intake without stimulant-based mechanisms.<\/p>\n\n\n\n
Supported by more than a decade of research, including preclinical investigations and a 12-week placebo-controlled clinical trial in over 300 overweight adults, supplementation with Hafnia alvei HA4597 alongside a calorie-restricted diet made participants 50% more likely to lose more than 4% of their body weight compared to diet alone. Survey findings further reported improvements in eating behaviors, greater post-meal fullness, and reduced cravings, reinforcing its positioning as a science-driven, non-stimulant approach to weight management.<\/p>\n\n\n\n