Creatine, a conditionally essential nutrient critical for cellular energy metabolism, lacks established dietary reference intakes (DRIs) despite its well-documented physiological role. This analysis integrates data on creatine turnover, endogenous synthesis, and dietary exposure to propose evidence-based adequate intake (AI) values for adults aged 19\u201365 years. Daily creatine losses via irreversible conversion to creatinine are estimated at ~20 mg\/kg\/day in men and ~15 mg\/kg\/day in women, of which ~73% is met through endogenous synthesis and ~27% through diet. Accordingly, proposed AIs are 5.4 mg\/kg\/day for men (\u2248400 mg\/day for a 75 kg individual) and 4.1 mg\/kg\/day for women (\u2248240 mg\/day for a 60 kg individual). While typical omnivorous diets are likely sufficient, populations such as vegetarians, vegans, older adults, and those with limited access to animal-source foods may be at risk of suboptimal creatine status. These findings position creatine as a conditionally essential nutrient and provide a practical framework for dietary planning, public health strategy, and targeted supplementation to address potential insufficiency.<\/p>\n\n\n\n