{"id":1735,"date":"2026-05-08T11:33:53","date_gmt":"2026-05-08T11:33:53","guid":{"rendered":"https:\/\/snips.nutrifytoday.com\/blog\/?p=1735"},"modified":"2026-05-08T11:33:53","modified_gmt":"2026-05-08T11:33:53","slug":"in-vitro-insights-on-a-gut-testis-axis-model-by-a-nutraceutical-combination-of-ceratonia-siliqua-ribonucleotides-and-bifidobacterium-longum","status":"publish","type":"post","link":"https:\/\/snips.nutrifytoday.com\/blog\/in-vitro-insights-on-a-gut-testis-axis-model-by-a-nutraceutical-combination-of-ceratonia-siliqua-ribonucleotides-and-bifidobacterium-longum\/","title":{"rendered":"In Vitro Insights on a Gut\u2013Testis Axis Model by a Nutraceutical Combination of Ceratonia siliqua, Ribonucleotides and Bifidobacterium longum"},"content":{"rendered":"\n<p>The MIX formulation (Carob, B. longum GA24, ribonucleotides) enhanced intestinal barrier integrity by boosting Caco-2 viability, tight junctions, butyrate synthesis, and reducing ROS. In the gut testis co-culture, MIX protected Sertoli cells against oxidative stress, improving viability, ATP\/NO production, and suppressing apoptotic and inflammatory markers. It further promoted Sertoli cell maturation and hormonal regulation, markedly increasing AR, p27, SGP-2, testosterone, and FSHR expression, thereby supporting spermatogenesis via the gut testis axis.<\/p>\n\n\n\n<p>Source : <a href=\"https:\/\/www.mdpi.com\/1661-3821\/6\/1\/19\">https:\/\/www.mdpi.com\/1661-3821\/6\/1\/19<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The MIX formulation (Carob, B. longum GA24, ribonucleotides) enhanced intestinal barrier integrity by boosting Caco-2 viability, tight junctions, butyrate synthesis, and reducing ROS. In the gut testis co-culture, MIX protected Sertoli cells against oxidative stress, improving viability, ATP\/NO production, and suppressing apoptotic and inflammatory markers. It further promoted Sertoli cell maturation and hormonal regulation, markedly [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1735","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts\/1735","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/comments?post=1735"}],"version-history":[{"count":1,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts\/1735\/revisions"}],"predecessor-version":[{"id":1736,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts\/1735\/revisions\/1736"}],"wp:attachment":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/media?parent=1735"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/categories?post=1735"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/tags?post=1735"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}