{"id":1778,"date":"2026-05-30T13:01:56","date_gmt":"2026-05-30T13:01:56","guid":{"rendered":"https:\/\/snips.nutrifytoday.com\/blog\/?p=1778"},"modified":"2026-05-30T13:01:56","modified_gmt":"2026-05-30T13:01:56","slug":"effects-of-n-trans-caffeoyltyramine-nct-and-n-trans-feruloyltyramine-nft-supplementation-in-individuals-with-diarrhea-predominantirritable-bowel-syndrome-ibs-d-results-from-a-randomized-double","status":"publish","type":"post","link":"https:\/\/snips.nutrifytoday.com\/blog\/effects-of-n-trans-caffeoyltyramine-nct-and-n-trans-feruloyltyramine-nft-supplementation-in-individuals-with-diarrhea-predominantirritable-bowel-syndrome-ibs-d-results-from-a-randomized-double\/","title":{"rendered":"Effects of N-Trans Caffeoyltyramine (NCT) and N-Trans Feruloyltyramine (NFT) Supplementation in Individuals with Diarrhea PredominantIrritable Bowel Syndrome (IBS-D): Results from a Randomized, Double-Blind, Placebo-Controlled Trial"},"content":{"rendered":"\n<p>This randomized, double\u2011blind, placebo\u2011controlled trial investigated the gut\u2011healing effects of the isolated hydroxycinnamic acid amide N\u2011trans caffeoyltyramine (NCT) in adults with diarrhea\u2011predominant IBS. Over three weeks, oral supplementation significantly improved intestinal barrier integrity, shown by a reduced Lactulose\/Mannitol ratio (\ud835\udc5d = 0.048), and lowered systemic inflammation through decreased lipopolysaccharide\u2011binding protein levels (\ud835\udc5d= 0.018) compared to placebo. These findings highlight NCT\u2019s potential as a safe, targeted therapy for strengthening gut barrier function and alleviating IBS\u2011D\u2013related inflammation.<\/p>\n\n\n\n<p>Source : <a href=\"https:\/\/www.jscimedcentral.com\/public\/assets\/articles\/preventivemedicine-7-1036.pdf\">https:\/\/www.jscimedcentral.com\/public\/assets\/articles\/preventivemedicine-7-1036.pdf<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This randomized, double\u2011blind, placebo\u2011controlled trial investigated the gut\u2011healing effects of the isolated hydroxycinnamic acid amide N\u2011trans caffeoyltyramine (NCT) in adults with diarrhea\u2011predominant IBS. Over three weeks, oral supplementation significantly improved intestinal barrier integrity, shown by a reduced Lactulose\/Mannitol ratio (\ud835\udc5d = 0.048), and lowered systemic inflammation through decreased lipopolysaccharide\u2011binding protein levels (\ud835\udc5d= 0.018) compared to [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1778","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts\/1778","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/comments?post=1778"}],"version-history":[{"count":1,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts\/1778\/revisions"}],"predecessor-version":[{"id":1779,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/posts\/1778\/revisions\/1779"}],"wp:attachment":[{"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/media?parent=1778"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/categories?post=1778"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/snips.nutrifytoday.com\/blog\/wp-json\/wp\/v2\/tags?post=1778"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}