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Prebiotic, Antimicrobial, and Anti- Inflammatory Effects of Pistachio Leaf-Derived Polyphenols
The study identified that pistachio (Pistacia vera) leaf waste can be transformed into a gut targeted bioactive phytocomplex with meaningful intestinal health benefits, and it systematically evaluated this potential using human intestinal models. The researchers prepared a polyphenol-rich pistachio leaf extract (PLE) and characterized its phenolic profile through analytical techniques. Prebiotic potential was demonstrated by… Read More
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Phosphatidylserine Supplement Improves Cognition in Mild cognitive impairment
In a 12-month randomized trial of 190 older adults with mild cognitive impairment, a supplement containing phosphatidylserine, ALA, and ginkgo flavonoids improved arithmetic ability, reasoning, and short-term memory versus placebo. It also increased serum ALA, DHA, EPA, and key neurotransmitters. ALA partly mediated memory benefits. Source : https://pubmed.ncbi.nlm.nih.gov/39317299/ Read More
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Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration
Reports that inhibition of the age-associated gerozyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH) restores articular (hyaline) cartilage in aged and injured joints by reprogramming resident chondrocytes rather than activating stem cells. 15-PGDH, which increases with age and degrades prostaglandin E2 (PGE2), drives cartilage thinning, inflammation, and osteoarthritis (OA) progression. Pharmacological blockade of 15-PGDH in aged and ACL-injured mice… Read More
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Pain Signals That Heal: How Nerves Orchestrate Bone Repair
New research from Johns Hopkins Medicine has revealed a surprising role for pain-sensing nerves in bone fracture healing. Far from acting only as alarm systems that signal injury, sensory neurons actively guide the repair process. In mouse models, these “pain pathways” were shown to transform after a fracture—from nociceptors that report pain and inflammation into… Read More
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DIM: The Natural Compound Battling Tooth-Decaying Bacteria and Biofilms
Indole, a byproduct of the amino acid tryptophan, acts as a bacterial signal that drives biofilm formation including the tooth-clinging plaques linked to oral infections and dental caries. These biofilms, major public health threats, form complex structures on teeth via pioneer microbes like Streptococcus mutans, the prime culprit in cavities.Our study reveals that 3,3′-Diindolylmethane (DIM),… Read More