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The study evaluated yeast protein (YP) as a sustainable alternative protein for supporting gut health in older adults by examining its effects on the gut microbiota, microbial metabolites, intestinal barrier function, and inflammation. Using the SIFR® model with fecal microbiota from six men aged 50–65 years, YP was compared with whey protein isolate (WPI) and Read More

This network meta-analysis of 163 RCTs (15,757 participants) evaluated 137 nutraceutical/phytoceutical interventions for major depressive disorder. EPA, vitamin D3, and St. John’s wort showed significant reductions in depressive symptoms, while curcumin improved anxiety symptoms. Despite these findings, high heterogeneity and low-to-very-low certainty of evidence limit clinical conclusions and highlight the need for larger, high-quality RCTs. Read More

Osteoprotective potential of Eucommia ulmoides Oliv., traditionally used in Chinese medicine for strengthening muscles and bones. E. ulmoides extracts and bioactive compounds such as aucubin, geniposide, geniposidic acid, quercetin, chlorogenic acid, and rutin were associated with improved bone formation, reduced osteoclast-mediated bone resorption, protection of cartilage, and suppression of inflammation and oxidative stress. The evidence Read More

Emerging evidence suggests that L-methylfolate can augment antidepressant response in major depressive disorder. This prospective, naturalistic study assessed changes in depression severity and treatment satisfaction after patients were prescribed L-methylfolate as a medical food, either alongside existing antidepressants or alone.Over three months, participants reported symptoms, functioning, and medication experiences using standardized measures. Patients described meaningful Read More

The nutraceutical landscape is seeing growing momentum around GLP-1 nutrition, targeted children’s supplements and specialized eye-health products. As GLP-1 medications reshape the weight-management market, the opportunity is expanding beyond the drugs themselves, with brands exploring nutritional solutions that can support consumers throughout their weight-management journey. Children’s nutrition is also moving beyond generic multivitamins, with increasing Read More