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Conflicting guidelines on low- and no-calorie sweeteners (LNCS) stem largely from how evidence is analyzed. This umbrella review evaluated whether analytical approach influences conclusions on LNCS and cardiometabolic health. Across randomized trials, LNCS consistently reduced energy intake, body weight, and body fat. Bias-adjusted analyses also showed reductions in BMI and systolic blood pressure, with modest… Read More

This review analyzed 23 RCTs on supplements for osteoarthritis. Passion fruit peel extract showed the strongest improvement in pain and function, followed by Lanconone and collagen. Source : https://pubmed.ncbi.nlm.nih.gov/40425393 Read More

Fish oil is rich in EPA and DHA, but these delicate omega-3 fats are highly prone to oxidation if exposed to air, heat, or poor storage. Oxidation doesn’t just affect taste, it can also reduce the nutritional integrity of the oil. Research shows that 30-45% of retail fish oil products may exceed recommended oxidation limits,… Read More

Could a common amino acid help sharpen the aging mind? A recent 10-week study suggests that β-alanine (BA) supplementation might improve cognitive function and mood in older adults.Researchers followed 100 participants, average age 71, who took either 2.4 grams of β-alanine or a placebo daily. They underwent memory, attention, and mood tests including the Montreal… Read More

This study identifies Siglec-10 as a dominant inhibitory glyco-immune checkpoint on tumor-associated macrophages (TAMs) in pancreatic ductal adenocarcinoma (PDAC) and demonstrates that PDAC cells evade innate and adaptive immunity by exploiting sialylated integrin α3β1 (ITGA3–ITGB1) as a functional ligand for Siglec-10. Mechanistically, α3β1 on PDAC cells is heavily sialylated, enabling high-affinity engagement of Siglec-10 on… Read More