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Enlicitide, the first oral PCSK9 inhibitor, which achieved ~60% reductions in LDL cholesterol in a large placebo‑controlled trial. The drug also lowered non‑HDL cholesterol, ApoB, and lipoprotein(a), with efficacy comparable to injectable PCSK9 therapies. Safety outcomes were similar to placebo, positioning enlicitide as a potent, convenient oral option for long‑term lipid management. Source : https://www.nejm.org/doi/10.1056/NEJMoa2511002 Read More

In an 8-week randomized trial, a supplement with sakura and Rosa roxburghii extract improved skin hydration (~25–28%), elasticity, collagen, texture, and reduced wrinkles and neck lines versus placebo. Safe and effective for skin aging. Source : https://pubmed.ncbi.nlm.nih.gov/41215693/ Read More

A daily multivitamin–multimineral (MVM) could do more than just fill nutrient gaps, it may subtly slow the biological aging process at the DNA level. In the COSMOS trial, 2 years of supplementation with Centrum Silver showed modest but statistically significant reductions in the progression of key epigenetic aging markers like PCGrimAge and PCPhenoAge, particularly in… Read More

Berberine, a plant alkaloid, shows promise in managing metabolic syndrome by improving glucose control, reducing insulin resistance, and supporting ovulation. It exerts anti-obesity, anti-sclerotic, and anti-inflammatory effects, while also offering neuroprotective and antidepressant benefits. Additionally, berberine demonstrates anticancer potential through apoptosis induction, cell cycle arrest, and modulation of MAPK and lipid metabolism. Source : https://pmc.ncbi.nlm.nih.gov/articles/PMC8874997/ Read More

Creatine, a conditionally essential nutrient critical for cellular energy metabolism, lacks established dietary reference intakes (DRIs) despite its well-documented physiological role. This analysis integrates data on creatine turnover, endogenous synthesis, and dietary exposure to propose evidence-based adequate intake (AI) values for adults aged 19–65 years. Daily creatine losses via irreversible conversion to creatinine are estimated… Read More