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Daily Italian Coffee Habit May Cut MASLD Risk by Over 50%
A population-based cohort study from Southern Italy demonstrates a clear inverse association between Italian-style coffee consumption and the risk of metabolic dysfunction-associated steatotic liver disease (MASLD), with a dose-dependent reduction observed as intake increases. Compared to individuals consuming less than one cup per day, those consuming 1, 2, and 3 cups daily showed progressively lower… Read More
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Identification and antidiabetic activity of peptides in protein Morus alba leaf proteolytic hydrolysates: A novel functional food ingredient for ameliorating type 2 diabetes mellitus
Mulberry leaf protein–derived bioactive peptides exert antidiabetic effects primarily by modulating key glucose-metabolic pathways and inhibiting carbohydrate-digesting enzymes. The identified peptides demonstrated strong α-glucosidase inhibitory activity, thereby delaying intestinal carbohydrate hydrolysis and reducing postprandial glucose absorption. Additionally, the peptides improved insulin sensitivity and glucose uptake, likely through activation of insulin-signaling pathways such as PI3K/Akt, leading… Read More
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Paeonia lactiflora root extract in controlling inflammation and supporting collagen I production
The study evaluated the root extract of Paeonia lactiflora, standardized for paeoniflorin, for its ability to modulate inflammation and protect tissue integrity in skin keratinocytes and oral gingival fibroblasts under inflammatory conditions. Using lipopolysaccharide (LPS) induced in vitro models along with in silico analysis, the extract reduced the activity of TRPV1 channels and lowered the… Read More
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A Multi-Target Strategy for Managing Rheumatoid Arthritis and Reducing Cardiovascular Disease Risk
Avocado peel derived nutraceutical demonstrates a promising multi-targeted approach in managing Rheumatoid Arthritis while simultaneously mitigating associated Cardiovascular Disease risk. Rich in bioactive compounds with strong antioxidant capacity, APN effectively reduces oxidative stress, systemic inflammation, and dyslipidemia, key drivers linking RA to cardiometabolic complications. Mechanistically, it downregulates pro-inflammatory mediators such as COX-2, IL-6, IL-1β, and… Read More
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Closing the Regulatory Divide in Nutraceuticals
Nutraceuticals products that bridge the gap between food and medicine are rapidly gaining global popularity. However, their growth is complicated by major differences in how countries regulate them. A comparison of the United States, India, and the European Union highlights how these varying frameworks impact both product safety and international market access.In the United States,… Read More