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The paper shows that expressing a yeast cytosolic DHODH (Sc URA) in mammalian cells decouples de novo pyrimidine biosynthesis from the mitochondrial electron-transport chain by using fumarate instead of ubiquinone as an electron acceptor, enabling respiration-independent nucleotide synthesis. As a result, cells with Sc URA resist inhibition of respiratory complex III or mitochondrial ribosomes and… Read More

In a 6-month randomized trial of 225 patients with androgenic alopecia, adding the AGA-P supplement (Serenoa repens, pumpkin extract, L-cystine, vitamin C) to minoxidil/finasteride significantly improved outcomes. Greater improvement occurred in 36.5% of the supplement group vs. 25% with drugs alone. Supplementation enhanced treatment effectiveness. Source : https://pubmed.ncbi.nlm.nih.gov/40853071/ Read More

This review establishes a “metabolic code” where Lactobacillus-derived metabolites, specifically SCFAs, function as epigenetic and signaling ligands that directly regulate bone remodeling via the activation of GPR41, GPR43, and GPR109A. The authors demonstrate that these microbial-host interactions suppress osteoclastogenesis by modulating the RANKL/OPG ratio and reducing systemic pro-inflammatory cytokines such as TNF-α and IL-6. Furthermore,… Read More

This study investigated the probiotic strains Lacticaseibacillus paracasei L9 and Bifidobacterium animalis subsp.lactis A6 for their potential to improve Alzheimer’s disease (AD) pathology through modulation of the gut brain axis in an AD mouse model. Oral administration of these probiotics improved learning and memory performance and helped restore hippocampal neuronal structure. The treatment reduced amyloid-β… Read More

Vitamin B12 deficiency is widespread among older adults, rising with age, and can manifest as macrocytic anemia, spinal cord degeneration, neuropathy, or remain asymptomatic; while treatment is clear for symptomatic cases with low plasma levels, its role without anemia or neuropathy remains uncertain. This randomized, double-blind, placebo-controlled trial assesses whether daily 1 mg oral crystalline… Read More