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This study identifies Siglec-10 as a dominant inhibitory glyco-immune checkpoint on tumor-associated macrophages (TAMs) in pancreatic ductal adenocarcinoma (PDAC) and demonstrates that PDAC cells evade innate and adaptive immunity by exploiting sialylated integrin α3β1 (ITGA3–ITGB1) as a functional ligand for Siglec-10. Mechanistically, α3β1 on PDAC cells is heavily sialylated, enabling high-affinity engagement of Siglec-10 on… Read More

Studies examining folate intake and breast cancer risk present a mixed and often conflicting picture, with some reporting a protective association, others finding no relationship, and a few suggesting a U-shaped effect where both low and high intakes may influence risk differently. This inconsistency likely reflects differences in baseline folate status, dietary versus supplemental sources,… Read More

A newly published clinical trial is set to reshape how the nutraceutical industry approaches NAD⁺ enhancement. In a peer-reviewed, randomized, double-blind, placebo-controlled study in the Journal of Functional Foods, researchers showed that the botanical complex BluNADBooster outperformed the long-standing benchmark NAD⁺ precursor, nicotinamide riboside (NR), across multiple healthy-ageing domains.The study demonstrated that BluNADBooster significantly improved… Read More

In this 8-week study on women aged 30–50, a supplement with cherry blossom (sakura) and Rosa roxburghii fruit extract improved several signs of skin aging compared to placebo. It increased skin hydration, brightness, elasticity, and collagen index, while reducing roughness, scaliness, and wrinkles—including forehead lines, crow’s feet, and neck lines. The supplement was safe and… Read More

A recent research suggests that what we eat may shape how well our brain ages and plant pigments called anthocyanins (found in berries, purple corn, black rice, etc.) look especially promising. A meta-analysis of 59 randomized controlled trials found that anthocyanin-rich supplements significantly improved overall cognitive performance compared to placebo. Benefits weren’t limited to just… Read More