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The study evaluated the cell-free supernatant (CFS) of Limosilactobacillus fermentum GBE18 for its potential to promote bone formation using MC3T3-E1 preosteoblast cells. The probiotic-derived CFS contains soluble metabolites and bioactive compounds released by L. fermentum GBE18, which enhanced osteogenic activity in the cells. Treatment increased markers associated with osteoblast differentiation and mineralization, with the effects Read More

The Accelerated Ovarian Failure (AOF) rodent model more closely replicates human perimenopause and postmenopause than traditional models. Low-dose VCD injections gradually deplete ovarian follicles, producing fluctuating and eventually undetectable estrogen levels while preserving ovarian tissue. This model helps separate the effects of aging from hormonal decline and may advance research on menopause-related memory, mood, and Read More

The gut microbiome is increasingly being recognised as a key regulator of metabolic health and healthy ageing, driving innovation beyond traditional digestive wellness solutions. Emerging research highlights that targeted microbiome interventions—including prebiotics, probiotics, postbiotics, and next-generation biotics—can enhance short-chain fatty acid (SCFA) production, improve gut barrier integrity, reduce chronic low-grade inflammation, and support glucose metabolism, Read More

A clinical trial suggests that nano-curcumin may help reduce inflammation and improve lung function in people with severe chronic obstructive pulmonary disease. Participants receiving nano-curcumin showed lower IL-6 levels, better respiratory performance, modest improvements in body weight and BMI, and improved systolic blood pressure compared with placebo. Source : https://pubmed.ncbi.nlm.nih.gov/38123239/ Read More

This study identified several DNA methylation changes associated with the development of insulin resistance over a 6-year period, with key epigenetic sites in genes such as REPIN1, BMP2, LINC01723, and SEL1L2. Higher vitamin B12 intake was associated with beneficial epigenetic modifications, particularly in REPIN1 and DNAAF9, which mediated reduced insulin resistance, whereas higher total sugar Read More