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High‑Dose Vitamin D in Multiple Sclerosis: Safe, Immunomodulatory, Clinical Benefit Unclear
High‑dose vitamin D (≥10,000 IU/day) safely raises 25‑hydroxy vitamin D with rare transient calcium changes and shows consistent immunomodulatory effects, especially reduced IL‑17 activity-but clinical and MRI benefits remain inconsistent. Larger, longer trials are needed to confirm whether immune changes translate into reduced relapses or disability. Source : https://pubmed.ncbi.nlm.nih.gov/42320168/ Read More
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No Quick Boost : Single-Dose Choline Doesn’t Improve Memory
Three double-blind, placebo-controlled crossover trials tested a single 2.0–2.5 g dose of choline bitartrate in healthy young adults. Tasks-visuospatial, verbal working memory, and declarative picture memorization were performed ~60 minutes after dosing (total N across studies = 94). Choline produced no significant memory benefits; Bayesian analyses strongly supported the null. Results suggest acute choline supplementation… Read More
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Effects of taurine supplementation on metabolic health and biological aging in healthcare workers: A protocol for a triple-blinded, Bayesian-optimized phase II randomized controlled trial
This Phase II, Bayesian-optimized randomized controlled trial aims to evaluate whether a 6-month oral taurine supplementation program (3 g/day) improves metabolic health and blood glucose control among healthcare workers. The evidence connecting taurine deficiency to age-related metabolic diseases, the study will randomize up to 80 participants to receive either taurine or a placebo, stratifying them… Read More
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Raising Potassium Lowers Arrhythmia Risk
In high-risk heart patients with ICDs, increasing potassium to high-normal levels (4.5–5.0 mmol/L) significantly reduced ventricular arrhythmias, hospitalizations, and death compared to standard care. Safety outcomes were similar. Maintaining higher potassium improved cardiovascular outcomes. Source : https://pubmed.ncbi.nlm.nih.gov/40879429/ Read More
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Panax quinquefolium saponin decreases atherosclerosis in ovariectomized ApoE−/− mice via regulating estrogen receptor α
This study investigated the effects of Panax quinquefolium saponin (PQS) on atherosclerosis in ovariectomized ApoE−/− mice, a model mimicking postmenopausal women. Ovariectomy increased plaque formation, inflammation, and endothelial apoptosis, but PQS treatment reduced these harmful changes at both early (8 weeks) and advanced (14 weeks) stages. Mechanistic analysis showed PQS acts through estrogen receptor α… Read More