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A randomized, double-masked crossover study in 12 sedentary overweight men found that high-intensity sprint exercise produced a clear short-term appetite-suppressing effect, whereas L-leucine supplementation alone had more modest and inconsistent impacts. Participants completed four conditions: exercise with leucine, exercise with placebo, leucine alone, and placebo alone. Both exercise trials reduced subjective appetite and food intake… Read More

Dietary supplements promise brain-boosting benefits, but do they deliver? The COSMOS-Mind study, a massive three-year trial involving over 2,200 older adults (average age 73, mostly women), put cocoa extract and daily multivitamins to the test against placebos.Researchers tracked cognition annually via phone interviews, measuring everything from memory recall and verbal fluency to problem-solving speed. The… Read More

The paper shows that expressing a yeast cytosolic DHODH (Sc URA) in mammalian cells decouples de novo pyrimidine biosynthesis from the mitochondrial electron-transport chain by using fumarate instead of ubiquinone as an electron acceptor, enabling respiration-independent nucleotide synthesis. As a result, cells with Sc URA resist inhibition of respiratory complex III or mitochondrial ribosomes and… Read More

In a 6-month randomized trial of 225 patients with androgenic alopecia, adding the AGA-P supplement (Serenoa repens, pumpkin extract, L-cystine, vitamin C) to minoxidil/finasteride significantly improved outcomes. Greater improvement occurred in 36.5% of the supplement group vs. 25% with drugs alone. Supplementation enhanced treatment effectiveness. Source : https://pubmed.ncbi.nlm.nih.gov/40853071/ Read More

This review establishes a “metabolic code” where Lactobacillus-derived metabolites, specifically SCFAs, function as epigenetic and signaling ligands that directly regulate bone remodeling via the activation of GPR41, GPR43, and GPR109A. The authors demonstrate that these microbial-host interactions suppress osteoclastogenesis by modulating the RANKL/OPG ratio and reducing systemic pro-inflammatory cytokines such as TNF-α and IL-6. Furthermore,… Read More