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This 12‑week randomized, double‑blind, placebo‑controlled trial found that adding a citrus bioflavonoid nutraceutical to metformin therapy in prediabetic individuals improved metabolic and clinical outcomes compared to metformin alone. The supplement group showed better postprandial glucose control, preserved GLP‑1 levels, reduced insulin resistance, lower TNF‑α, enhanced antioxidant capacity, modest reductions in body weight, fat mass, and… Read More

Improved surgery and immunosuppression have lengthened transplant survival, but chronic immunosuppressants cause frequent GI symptoms and long-term cardiometabolic risks (diabetes, dyslipidaemia, hypertension, malignancy). Emerging evidence links these harms to gut dysbiosis and increased intestinal permeability, which promote toxin production, bacterial translocation, and inflammation. Early studies testing diet, high‑dose synbiotics (prebiotics/probiotics/antibiotics) and fecal transplants suggest microbial… Read More

A randomized placebo-controlled trial in healthy adults found that a multi-species synbiotic (probiotic strains plus Indian pomegranate extract) taken alongside a short course of antibiotics accelerated recovery of the gut microbiome and its functions. Compared with placebo, the synbiotic raised diversity of Bifidobacterium and Lactobacillus, restored butyrate- and acetate-producing species (with large increases in fecal… Read More

This study on Mangifera indica seed for their biological activities, particularly their ability to protect against alcoholic liver disease and modulate gut microbiota. The researchers separated mango seed components into different fractions and found that polyphenol-rich fractions containing compounds such as gallic acid, ellagic acid, and gallotannins exhibited the strongest antioxidant and anti-inflammatory effects. In… Read More

In a randomized trial, a multi-species probiotic improved vagus nerve activity in patients with major depression after 3 months. Benefits included better heart rate variability, improved sleep, and increased beneficial gut bacteria such as Akkermansia muciniphila. Results suggest probiotics may support gut–brain communication and mental health. Source : https://pubmed.ncbi.nlm.nih.gov/40298641/ Read More