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This study evaluates the anti-asthmatic potential of Perilla frutescens, a plant traditionally used for its medicinal properties. Allergic asthma is a chronic inflammatory airway disease characterized by airway hyperresponsiveness, eosinophilic infiltration, and elevated levels of Th2 cytokines. In this study, mice were sensitized and challenged with allergens to induce asthma-like symptoms and were subsequently treated… Read More

This 1-month randomized, open-label clinical trial conducted in Cork, Ireland, evaluated the safety and tolerability of a Lactobacillus probiotic combined with herbal extracts in healthy volunteers and patients with asthma. Participants consumed the blend twice daily. The primary outcome of safety was met, with no adverse events reported. Asthmatic participants showed improvements in lung function… Read More

A new framework expands the classic 12 hallmarks of aging to 14, classifying them into three tiers: primary (root causes like genomic instability, telomere shortening, epigenetic alterations, loss of proteostasis, impaired macroautophagy), antagonistic (stress responses such as mitochondrial dysfunction, cellular senescence, deregulated nutrient sensing), and integrative (observable consequences like chronic inflammation, stem cell exhaustion, altered… Read More

Mango leaf extract, rich in the polyphenol mangiferin, is widely touted for its potential brain health benefits, but not all studies agree on its effectiveness. In a recent gold-standard trial, healthy adults given a single 300 mg dose of mango leaf extract saw no improvements in cognitive performance or mood; in fact, they made more… Read More

A new analysis of U.S. children and adolescents finds that higher blood levels of carotenoids are linked to lower obesity risk. Using NHANES 2017–2018 data from 1,329 participants, researchers reported that all carotenoids studied except lycopene were associated with lower BMI and reduced odds of obesity. β-carotene showed the strongest effect, while the combined carotenoid… Read More